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Beyond the skin: B cells in pemphigus vulgaris, tolerance and treatment

19 Mar 2024

Abstract excerpt

Pemphigus vulgaris (PV) is a rare autoimmune bullous disease characterized by blistering of the skin and mucosa owing to the presence of autoantibodies against the desmosome proteins desmoglein 3 and occasionally in conjunction with desmoglein 1. Fundamental research into the pathogenesis of PV has revolutionized its treatment and outcome with rituximab, a B-cell-depleting therapy. The critical contribution of B...

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PMID: 38504438
DOI: 10.1093/bjd/ljae107

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