Article
Distinct impact of IgG subclass and Fc-FcγR interaction on autoantibody pathogenicity in different IgG4-mediated diseases
2020-12-08
Abstract excerpt
IgG4 is the least potent human IgG subclass for the FcγR-mediated antibody effector function and is considered anti-inflammatory in the context of prolonged inflammation and allergic responses. Paradoxically, IgG4 is also the dominant IgG subclass of pathogenic autoantibodies in IgG4-mediated diseases. Here we show that the IgG subclass and Fc-FcγR interaction have a distinct impact on the pathogenic function of a...
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Identifiers and source
- Literature Corpus work
- acb0cbab-5007-583f-9401-b4e36b2dac5d
- DOI
- 10.1101/2020.12.07.20243774