Article
Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes.
Genesis (New York, N.Y. : 2000) - 1 Dec 2005
Galy Bruno, Ferring Dunja, Hentze Matthias W
Abstract excerpt
Central aspects of cellular iron metabolism are controlled by IRP1 and IRP2, which are ubiquitously expressed in mouse organs and cells. Total and constitutive deficiency of both IRPs causes embryonic lethality in the mouse. To bypass the early lethality and to study organ-specific and/or temporal functions of IRP1 and/or IRP2 we generated Irp1 and Irp2 conditional alleles. We used mouse lines where a betaGeo...
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