Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of Osr1 conditional mutant mice.

Genesis (New York, N.Y. : 2000) - 1 May 2011

Lan Yu, Liu Han, Ovitt Catherine E, Jiang Rulang

Abstract excerpt

The Odd-skipped related 1 (Osr1) gene encodes a zinc finger protein homologous to the Drosophila Odd-skipped transcription factor. During mouse embryogenesis, Osr1 is expressed in multiple tissues, including the developing heart, kidney, limb, lung, and craniofacial structures. Although characterization of targeted mutant mice has revealed essential roles for Osr1 in heart and kidney development, the embryonic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryo, Mammalian
Share to Exons
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Homozygote

Share to Mice, Knockout

Share to Mice, Transgenic

Share to Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 21462293
DOI: 10.1002/dvg.20734
PMCID: PMC3096694

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of Osr1 conditional mutant mice.PMID 21462293Read ↗

Zinc-finger transcription factor Odd-skipped related 1 regulates cranial bone formation.Semantic proximity Read ↗

Heterozygous loss-of-function mutation in Odd-skipped related 1 (Osr1) is associated with vesicoureteric reflux, duplex systems, and hydronephrosis.Semantic proximity Read ↗

Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes.Semantic proximity Read ↗

<i>osr1</i> maintains renal progenitors and regulates podocyte development by promoting <i>wnt2ba</i> through antagonism of <i>hand2</i>Semantic proximity Read ↗

osr1 Maintains Renal Progenitors and Regulates Podocyte Development by Promoting wnt2ba via the Antagonism of hand2Semantic proximity Read ↗

Kidney adysplasia and variable hydronephrosis, a new mutation affecting the odd-skipped related 1 gene in the mouse, causes variable defects in kidney development and hydronephrosis.Semantic proximity Read ↗

Two new targeted alleles for the comprehensive analysis of Meis1 functions in the mouse.Semantic proximity Read ↗

Mouse models in the study of the Ets family of transcription factors.Semantic proximity Read ↗

Conditional inactivation of the mouse Wwox tumor suppressor gene recapitulates the null phenotype.Semantic proximity Read ↗

Osr1 functions downstream of Hedgehog pathway to regulate foregut development.Semantic proximity Read ↗

A CRISPR/Cas9-engineered mouse carrying a conditional knockout allele for the early growth response-1 transcription factor.Semantic proximity Read ↗

Generation of the floxed allele of the SIP1 (Smad-interacting protein 1) gene for Cre-mediated conditional knockout in the mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.