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Article

The molecular circuitry regulating the switch between iron deficiency and overload in mice.

The Journal of biological chemistry - 24 Mar 2006

Mok Henry, Mlodnicka Agnieszka E, Hentze Matthias W, Muckenthaler Martina, Schumacher Armin

Abstract excerpt

Recent positional cloning of the radiation-induced polycythaemia (Pcm) mutation revealed a 58-bp microdeletion in the promoter region of ferroportin 1 (Fpn1), the sole cellular iron exporter identified to date. Here we report a molecular definition of the regulatory mechanisms governing the dynamic changes in iron balance in Pcm heterozygous mice between 3 and 12 weeks of age. Hepatic and/or duodenal response...

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Identifiers

PMID: 16418170
DOI: 10.1074/jbc.M509857200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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