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Identification of novel SNPs by next-generation sequencing of the genomic region containing the APC gene in colorectal cancer patients in China.

Omics : a journal of integrative biology - 1 Jun 2010

Cheng Yin, Wang Jun, Shao Jiaofang, Chen Qiyun, Mo Fan, Ma Liang, Han Xu, Zhang Jing, Chen Chen, Zhang Cixiong, Lin Shuyong, Yu Jiekai, Zheng Shu, Lin Sheng-Cai, Lin Biaoyang

Abstract excerpt

We described an approach of identifying single nucleotide polymorphisms (SNPs) in complete genomic regions of key genes including promoters, exons, introns, and downstream sequences by combining long-range polymerase chain reaction (PCR) or NimbleGen sequence capture with next-generation sequencing. Using the adenomatous polyposis coli (APC) gene as an example, we identified 210 highly reliable SNPs by...

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PMID: 20569184
DOI: 10.1089/omi.2010.0018

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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