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Article

Translation of an STR-based biomarker into a clinically compatible SNP-based platform for loss of heterozygosity.

Cancer biomarkers : section A of Disease markers - 1 Jan 2009

Kissel Heather D, Galipeau Patricia C, Li Xiaohong, Reid Brian J

Abstract excerpt

Loss of heterozygosity (LOH) has been shown to be a promising biomarker of cancer risk in patients with premalignant conditions. In this study we describe analytical validation in clinical biopsy samples of a SNP-based pyrosequencing panel targeting regions of LOH on chromosomes 17p and 9p including TP53 and CDKN2A tumor suppressor genes. Assays were tested for analytic specificity, sensitivity, efficiency, and...

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Source

Open in PubMed Open full text

Identifiers

PMID: 19407369
DOI: 10.3233/CBM-2009-0618
PMCID: PMC2861428

Genes

CDKN2A
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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