Article
Mass spectrometry-based loss of heterozygosity analysis of single-nucleotide polymorphism loci in paraffin embedded tumors using the MassEXTEND assay: single-nucleotide polymorphism loss of heterozygosity analysis of the protein tyrosine phosphatase receptor type J in familial colorectal cancer.
The Journal of molecular diagnostics : JMD - 1 Nov 2005
van Puijenbroek Marjo, Dierssen Jan Willem F, Stanssens Patrick, van Eijk Ronald, Cleton-Jansen Anne Marie, van Wezel Tom, Morreau Hans
Abstract excerpt
As the number of identified single-nucleotide polymorphisms (SNPs) increases, high-throughput methods are required to characterize the informative loci in large patient series. We investigated the feasibility of MassEXTEND LOH analysis using Sequenom's MassArray RT software, a mass spectrometry method, as an alternative to determine loss of heterozygosity (LOH). For this purpose, we studied the c.827A>C SNP...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.