Article
Physical function and its response to exercise: associations with cytokine gene variation in older adults with knee osteoarthritis.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Oct 2005
Nicklas Barbara J, Mychaleckyj Joe, Kritchevsky Stephen, Palla Shana, Lange Leslie A, Lange Ethan M, Messier Stephen P, Bowden Don, Pahor Marco
Abstract excerpt
BACKGROUND: We determined whether physical function and its response to exercise training are associated with polymorphisms in cytokine genes (interleukin-6 [IL-6] -174 G/C; tumor necrosis factor alpha [TNFalpha] -308 G/A and -238 G/A; and TNFalpha receptors [TNFR]1 +36 A/G, TNFR2 +676 T/G, and TNFR2 +1663 A/G), in 214 older (> or =60 years), overweight (body mass index > or =28 kg/m(2)) individuals with knee...
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