Article
Associations of TNF-α and IL-6 polymorphisms with osteoporosis through joint effects and interactions with LEPR gene in Taiwan: Taichung Community Health Study for Elders (TCHS-E).
Molecular biology reports - 1 Oct 2016
Lin Cheng-Chieh, Li Tsai-Chung, Liu Chiu-Shong, Yang Chuan-Wei, Lin Chih-Hsueh, Hsiao Jen-Hao, Meng Nai-Hsin, Lin Wen-Yuan, Liao Li-Na, Li Chia-Ing, Wu Fang-Yang
Abstract excerpt
Osteoporosis (OST) is a complex multifactorial disease considered to result from interactions of multiple gene and environmental factors. Tumor necrosis factor (TNF)-α and interleukin (IL)-6 are pleiotropic cytokines essential for bone remodeling; and hormone leptin has immunomodulatory effects that stimulate the synthesis of IL-6 and TNF-α. Leptin is involved in the modulation of bone growth and turnover; and...
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