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Article

Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans.

American journal of medical genetics. Part A - 30 Apr 2004

Marks Daniel L, Boucher Nathalie, Lanouette Christian-Marc, Pérusse Louis, Brookhart Gregor, Comuzzie Anthony G, Chagnon Yvon C, Cone Roger D

Abstract excerpt

A role for melanocortin signaling in the regulation of body weight in humans has been clearly established. Haploinsufficiency of the type 4 melanocortin receptor is associated with early-onset obesity, implying that this receptor provides an important tonic inhibition of weight gain. Agouti-relat...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15054840
DOI: 10.1002/ajmg.a.20600

Genes

AGRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15054840-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans.PMID 15054840Read ↗

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A polymorphism in the human agouti-related protein is associated with late-onset obesity.Semantic proximity Read ↗

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Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity.Semantic proximity Read ↗

Association between a rare SNP in the second intron of human Agouti related protein gene and increased BMI.Semantic proximity Read ↗

Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity.Semantic proximity Read ↗

Two ethnic-specific polymorphisms in the human Agouti-related protein gene are associated with macronutrient intake.Semantic proximity Read ↗

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