Article
Association between a rare SNP in the second intron of human Agouti related protein gene and increased BMI.
BMC medical genetics - 14 Jul 2009
Kalnina Ineta, Kapa Ivo, Pirags Valdis, Ignatovica Vita, Schiöth Helgi B, Klovins Janis
Abstract excerpt
BACKGROUND: The agouti related protein (AGRP) is an endogenous antagonist of the melanocortin 4 receptor and is one of the most potent orexigenic factors. The aim of the present study was to assess the genetic variability of AGRP gene and investigate whether the previously reported SNP rs5030980 and the rs11575892, a SNP that so far has not been studied with respect to obesity is associated with increased body...
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