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Article

Different regions in skeletal and cardiac muscle ryanodine receptors are involved in transducing the functional effects of calmodulin.

The Journal of biological chemistry - 27 Aug 2004

Yamaguchi Naohiro, Xu Le, Evans Kelly E, Pasek Daniel A, Meissner Gerhard

Abstract excerpt

Calmodulin (CaM) inhibits the skeletal muscle ryanodine receptor-1 (RyR1) and cardiac muscle RyR2 at micromolar Ca(2+) but activates RyR1 and inhibits RyR2 at submicromolar Ca(2+) by binding to a single, highly conserved CaM-binding site. To identify regions responsible for the differential regulation of RyR1 and RyR2 by CaM, we generated chimeras encompassing and flanking the CaM-binding domain. We found that...

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Identifiers

PMID: 15215235
DOI: 10.1074/jbc.M405834200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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