Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Calmodulin-binding locations on the skeletal and cardiac ryanodine receptors.

The Journal of biological chemistry - 31 Aug 2012

Huang Xiaojun, Fruen Bradley, Farrington Dinah T, Wagenknecht Terence, Liu Zheng

Abstract excerpt

Ryanodine receptor types 1 (RyR1) and 2 (RyR2) are calcium release channels that are highly enriched in skeletal and cardiac muscle, respectively, where they play an essential role in excitation-contraction coupling. Apocalmodulin (apo-CaM) weakly activates RyR1 but inhibits RyR2, whereas Ca(2+)-...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Calmodulin
Share to Cryoelectron Microscopy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Muscle Proteins

Share to Muscle, Skeletal

Share to Myocardium

Share to Ryanodine Receptor Calcium Release Channel

Source

Open in PubMed Open full text

Identifiers

PMID: 22773841
DOI: 10.1074/jbc.M112.383109
PMCID: PMC3436284

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22773841-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Calmodulin-binding locations on the skeletal and cardiac ryanodine receptors.PMID 22773841Read ↗

Structural Details of the Ryanodine Receptor Calcium Release Channel and Its Gating Mechanism.Semantic proximity Read ↗

Lobe-specific calmodulin binding to different ryanodine receptor isoforms.Semantic proximity Read ↗

Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.Semantic proximity Read ↗

Different regions in skeletal and cardiac muscle ryanodine receptors are involved in transducing the functional effects of calmodulin.Semantic proximity Read ↗

Site-specific modification of calmodulin Ca²(+) affinity tunes the skeletal muscle ryanodine receptor activation profile.Semantic proximity Read ↗

Molecular basis of calmodulin binding to cardiac muscle Ca(2+) release channel (ryanodine receptor).Semantic proximity Read ↗

Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM.Semantic proximity Read ↗

Toward decrypting the allosteric mechanism of the ryanodine receptor based on coarse-grained structural and dynamic modeling.Semantic proximity Read ↗

RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation.Semantic proximity Read ↗

Half-calcified calmodulin promotes basal activity and inactivation of the L-type calcium channel CaV1.2.Semantic proximity Read ↗

Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2.Semantic proximity Read ↗

Apocalmodulin and Ca2+ calmodulin-binding sites on the CaV1.2 channel.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.