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Article

Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3.

Pflugers Archiv : European journal of physiology - 1 Dec 1998

Ikemoto T, Takeshima H, Iino M, Endo M

Abstract excerpt

We analyzed the effects of calmodulin (CaM) on Ca2+-induced Ca2+ release (CICR) in mouse skeletal muscle cells expressing only ryanodine receptor type 1 (RyR-1) or type 3 (RyR-3) following targeted disruption of one of the RyR genes. Under Mg2+-free conditions, CaM potentiated CICR via RyR-3 at low Ca2+ concentrations (pCa>/=6) but inhibited CICR at high Ca2+ concentrations (pCa</=5). On the other hand, CaM...

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PMID: 9817784
DOI: 10.1007/s004240050744

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