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Article

Proteomic scan for tyrosinase peptide antigenic pattern in vitiligo and melanoma: role of sequence similarity and HLA-DR1 affinity.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2005

Lucchese Alberta, Willers Jörg, Mittelman Abraham, Kanduc Darja, Dummer Reinhard

Abstract excerpt

Immune responses contribute to the pathogenesis of vitiligo and target melanoma sometimes associated with vitiligo-like depigmentation in some melanoma patients. We analyzed the sera from patients with vitiligo and cutaneous melanoma for reactivity toward tyrosinase peptide sequences 1) endowed with low level of similarity to human proteome, and 2) potentially able to bind HLA-DR1 Ags. We report that the...

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Identifiers

PMID: 16272362
DOI: 10.4049/jimmunol.175.10.7009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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