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Article

Proteomic Analysis of Pemphigus Autoantibodies Indicates a Larger, More Diverse, and More Dynamic Repertoire than Determined by B Cell Genetics.

Cell reports - 3 Jan 2017

Chen Jing, Zheng Qi, Hammers Christoph M, Ellebrecht Christoph T, Mukherjee Eric M, Tang Hsin-Yao, Lin Chenyan, Yuan Huijie, Pan Meng, Langenhan Jana, Komorowski Lars, Siegel Don L, Payne Aimee S, Stanley John R

Abstract excerpt

In autoantibody-mediated diseases such as pemphigus, serum antibodies lead to disease. Genetic analysis of B cells has allowed characterization of antibody repertoires in such diseases but would be complemented by proteomic analysis of serum autoantibodies. Here, we show using proteomic analysis that the serum autoantibody repertoire in pemphigus is much more polyclonal than that found by genetic studies of B...

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Identifiers

PMID: 28052253
DOI: 10.1016/j.celrep.2016.12.013
PMCID: PMC5221611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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