Article
Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth.
Science (New York, N.Y.) - 4 Nov 2005
Yoshihara Motojiro, Adolfsen Bill, Galle Kathleen T, Littleton J Troy
Abstract excerpt
The molecular pathways involved in retrograde signal transduction at synapses and the function of retrograde communication are poorly understood. Here, we demonstrate that postsynaptic calcium 2+ ion (Ca2+) influx through glutamate receptors and subsequent postsynaptic vesicle fusion trigger a robust induction of presynaptic miniature release after high-frequency stimulation at Drosophila neuromuscular junctions....
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