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Article

The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin.

Structure (London, England : 1993) - 1 Nov 2005

Giannetti Anthony M, Halbrooks Peter J, Mason Anne B, Vogt Todd M, Enns Caroline A, Björkman Pamela J

Abstract excerpt

Human transferrin receptor 1 (TfR) binds iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes where iron is released in a TfR-facilitated process. Consistent with our hypothesis that TfR binding stimulates iron release from Fe-Tf at acidic pH by stabilizing the apo-Tf conformation, a TfR mutant (W641A/F760A-TfR) that binds Fe-Tf, but not apo-Tf, cannot stimulate iron release from Fe-Tf, and less...

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Identifiers

PMID: 16271884
DOI: 10.1016/j.str.2005.07.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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