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Article

Identification of a kinetically significant anion binding (KISAB) site in the N-lobe of human serum transferrin.

Biochemistry - 18 May 2010

Byrne Shaina L, Steere Ashley N, Chasteen N Dennis, Mason Anne B

Abstract excerpt

Human serum transferrin (hTF) binds two ferric iron ions which are delivered to cells in a transferrin receptor (TFR) mediated process. Critical to the delivery of iron to cells is the binding of hTF to the TFR and the efficient release of iron orchestrated by the interaction. Within the endosome, iron release from hTF is also aided by lower pH, the presence of anions, and a chelator yet to be identified. We have...

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Identifiers

PMID: 20397659
DOI: 10.1021/bi1003519
PMCID: PMC3197725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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