Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake.

The Biochemical journal - 1 Apr 2002

Mulero Victoriano, Searle Susan, Blackwell Jenefer M, Brock Jeremy H

Abstract excerpt

Solute carrier 11a1 (Slc11a1; formerly Nramp1; where Nramp stands for natural-resistance-associated macrophage protein) is a proton/bivalent cation antiporter that localizes to late endosomes/lysosomes and controls resistance to pathogens. In the present study the role of Slc11a1 in iron turnover is examined in macrophages transfected with Slc11a1(Gly169) (wild-type) or Slc11a1(Asp169) (mutant=functional null)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cation Transport Proteins
Share to Cations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endosomes

Share to Lysosomes

Share to Nitric Oxide

Share to Nitrites

Share to Phagocytosis

Share to Transferrin

Source

Open in PubMed Open full text

Identifiers

PMID: 11903051
DOI: 10.1042/0264-6021:3630089
PMCID: PMC1222455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake.PMID 11903051Read ↗

Nramp1 modulates iron homoeostasis in vivo and in vitro: evidence for a role in cellular iron release involving de-acidification of intracellular vesicles.Semantic proximity Read ↗

Functional expression of Nramp1 in vitro in the murine macrophage line RAW264.7.Semantic proximity Read ↗

Localisation of Nramp1 in macrophages: modulation with activation and infection.Semantic proximity Read ↗

Function and Mechanism of Action of Dictyostelium Nramp1 (Slc11a1) in Bacterial InfectionSemantic proximity Read ↗

Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane.Semantic proximity Read ↗

Incomplete glycosylation and defective intracellular targeting of mutant solute carrier family 11 member 1 (Slc11a1).Semantic proximity Read ↗

Expression of the SLC11A1 (NRAMP1) 5'-(GT)n repeat: opposite effect in the presence of -237C-->T.Semantic proximity Read ↗

Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story.Semantic proximity Read ↗

Recent progress in structure-function analyses of Nramp proton-dependent metal-ion transporters.Semantic proximity Read ↗

Emerging Concepts in Defective Macrophage Phagocytosis in Cystic FibrosisSemantic proximity Read ↗

The Nramp1 protein and its role in resistance to infection and macrophage function.Semantic proximity Read ↗

Nramp1 locus encodes a 65 kDa interferon-γ-inducible protein in murine macrophagesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.