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Article

Mechanism for multiple ligand recognition by the human transferrin receptor.

PLoS biology - 1 Dec 2003

Giannetti Anthony M, Snow Peter M, Zak Olga, Björkman Pamela J

Abstract excerpt

Transferrin receptor 1 (TfR) plays a critical role in cellular iron import for most higher organisms. Cell surface TfR binds to circulating iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes, where low pH promotes iron to dissociate from transferrin (Tf) in a TfR-assisted process. The iron-free form of Tf (apo-Tf) remains bound to TfR and is recycled to the cell surface, where the complex...

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Source

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Identifiers

PMID: 14691533
DOI: 10.1371/journal.pbio.0000051
PMCID: PMC300677

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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