Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor.

Journal of lipid research - 1 Feb 2010

Huang Sha, Henry Lisa, Ho Yiu Kee, Pownall Henry J, Rudenko Gabby

Abstract excerpt

The LDL receptor (LDL-R) mediates cholesterol metabolism in humans by binding and internalizing cholesterol transported by LDL. Several different molecular mechanisms have been proposed for the binding of LDL to LDL-R at neutral plasma pH and for its release at acidic endosomal pH. The crystal structure of LDL-R at acidic pH shows that the receptor folds back on itself in a closed form, obscuring parts of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crystallography, X-Ray
Share to Epidermal Growth Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrogen-Ion Concentration

Share to Lipoproteins, LDL

Share to Mutagenesis, Site-Directed

Share to Protein Conformation

Share to Receptors, LDL

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 19674976
DOI: 10.1194/jlr.M000422
PMCID: PMC2803231

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor.PMID 19674976Read ↗

The LDL receptor: how acid pulls the trigger.Semantic proximity Read ↗

Structure of the LDL receptor extracellular domain at endosomal pH.Semantic proximity Read ↗

Structure and physiologic function of the low-density lipoprotein receptor.Semantic proximity Read ↗

Mechanism of low density lipoprotein (LDL) release in the endosome: implications of the stability and Ca2+ affinity of the fifth binding module of the LDL receptor.Semantic proximity Read ↗

Low-density lipoprotein receptor structure and folding.Semantic proximity Read ↗

Apolipoprotein E-low density lipoprotein receptor binding: study of protein-protein interaction in rationally selected docked complexes.Semantic proximity Read ↗

Role of an intramolecular contact on lipoprotein uptake by the LDL receptor.Semantic proximity Read ↗

Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor.Semantic proximity Read ↗

Low pH-triggered beta-propeller switch of the low-density lipoprotein receptor assists rhinovirus infection.Semantic proximity Read ↗

Low-density lipoprotein receptor--its structure, function, and mutations.Semantic proximity Read ↗

Differences in Recycling of Apolipoprotein E3 and E4-LDL Receptor Complexes-A Mechanistic Hypothesis.Semantic proximity Read ↗

Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.