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Article

Release of the soluble transferrin receptor is directly regulated by binding of its ligand ferritransferrin.

The Journal of biological chemistry - 10 Feb 2006

Dassler Katrin, Zydek Martin, Wandzik Krzysztof, Kaup Matthias, Fuchs Hendrik

Abstract excerpt

The human transferrin receptor (TfR) is shed by an integral metalloprotease releasing a soluble form (sTfR) into serum. The sTfR reflects the iron demand of the body and is postulated as a regulator of iron homeostasis via binding to the hereditary hemochromatosis protein HFE. To study the role of transferrin in this process, we investigated TfR shedding in HL60 cells and TfR-deficient Chinese hamster ovary cells...

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Source

Identifiers

PMID: 16354665
DOI: 10.1074/jbc.M511341200

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Release of the soluble transferrin receptor is directly regulated by binding of its ligand ferritransferrin.PMID 16354665Read ↗

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