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Article

Ionic residues of human serum transferrin affect binding to the transferrin receptor and iron release.

Biochemistry - 17 Jan 2012

Steere Ashley N, Miller Brendan F, Roberts Samantha E, Byrne Shaina L, Chasteen N Dennis, Smith Valerie C, MacGillivray Ross T A, Mason Anne B

Abstract excerpt

Efficient delivery of iron is critically dependent on the binding of diferric human serum transferrin (hTF) to its specific receptor (TFR) on the surface of actively dividing cells. Internalization of the complex into an endosome precedes iron removal. The return of hTF to the blood to continue the iron delivery cycle relies on the maintenance of the interaction between apohTF and the TFR after exposure to...

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Source

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Identifiers

PMID: 22191507
DOI: 10.1021/bi201661g
PMCID: PMC3267578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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