Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Transferrin Promotes Oligodendroglial Differentiation Independently of Iron Binding and Release.

ASN neuro - 1 Jan 2026

Chamorro-Aguirre Estefania, Garmendia Martina, Pérez María Julia, Franco Paula G, Byrne Agustín, Adamo Hugo, Correale Jorge, Pasquini Juana María

Abstract excerpt

Transferrin (Tf), classically known as the major iron-transport protein in mammals, also engages in potent promyelinating activity within the central nervous system by accelerating oligodendrocyte maturation. Since 1994, our group has shown that intrathecal or intranasal administration of apoTransferrin (aTf) promotes oligodendroglial differentiation and myelin protein expression in vivo and in vitro. A...

Topics

Join the communities discussing this publication.

Cell Differentiation
Cell Line
Iron
Myelin Basic Protein
Oligodendroglia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Transferrin

Source

Open in PubMed Open full text

Identifiers

PMID: 42635102
DOI: 10.1080/17590914.2026.2720203
PMCID: PMC13505439

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transferrin Promotes Oligodendroglial Differentiation Independently of Iron Binding and Release.PMID 42635102Read ↗

Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron ChelationSemantic proximity Read ↗

Paradoxes in the Ontological Classification of Glia- Evidence for an Important New Class of Brain Cells with Primary Functions in Iron RegulationSemantic proximity Read ↗

The Proteomics Study of Compounded HFE/TF/TfR2/HJV Genetic Variations in a Thai Family with Iron Overload, Chronic Anemia, and Motor Neuron Disorder.Semantic proximity Read ↗

Development and Characterization of Human Oligodendroglioma Cellular Model as a Useful Tool to Study Iron Role in Tumor Cell: Preliminary Results and Future ProspectiveSemantic proximity Read ↗

Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration.Semantic proximity Read ↗

NewroBus for the brain: humanized TfR1-targeting nanobodies with high BBB permeability and cargo transport capacitySemantic proximity Read ↗

The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin.Semantic proximity Read ↗

A novel human organoid model system reveals requirement of TCF4 for oligodendroglial differentiation.Semantic proximity Read ↗

Ionic residues of human serum transferrin affect binding to the transferrin receptor and iron release.Semantic proximity Read ↗

The Divalent Metal Transporter 1 (DMT1) Is Required for Iron Uptake and Normal Development of Oligodendrocyte Progenitor CellsSemantic proximity Read ↗

An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene deliverySemantic proximity Read ↗

Cryo-EM structures and functional characterization of homo- and heteropolymers of human ferritin variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.