Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The LDL receptor: how acid pulls the trigger.

Trends in biochemical sciences - 1 Jun 2005

Beglova Natalia, Blacklow Stephen C

Abstract excerpt

The low-density lipoprotein receptor normally carries lipoprotein particles into cells, and releases them upon delivery to the low pH milieu of the endosome. Recent structural and functional studies of the receptor, combined with the plethora of prior knowledge about normal receptor function and the effects of disease-associated mutations that cause familial hypercholesterolemia, reveal a detailed molecular model...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Endosomes
Share to Epidermal Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrogen-Ion Concentration

Share to Hyperlipoproteinemia Type II

Share to Protein Structure, Tertiary

Share to Receptors, LDL

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 15950875
DOI: 10.1016/j.tibs.2005.03.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The LDL receptor: how acid pulls the trigger.PMID 15950875Read ↗

Structure and physiologic function of the low-density lipoprotein receptor.Semantic proximity Read ↗

Structure of the LDL receptor extracellular domain at endosomal pH.Semantic proximity Read ↗

Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor.Semantic proximity Read ↗

Mechanism of low density lipoprotein (LDL) release in the endosome: implications of the stability and Ca2+ affinity of the fifth binding module of the LDL receptor.Semantic proximity Read ↗

RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi.Semantic proximity Read ↗

Low pH-triggered beta-propeller switch of the low-density lipoprotein receptor assists rhinovirus infection.Semantic proximity Read ↗

Role of an intramolecular contact on lipoprotein uptake by the LDL receptor.Semantic proximity Read ↗

Familial hypercholesterolemia: dissection of a receptor disease.Semantic proximity Read ↗

Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screeningSemantic proximity Read ↗

Low-density lipoprotein receptor structure and folding.Semantic proximity Read ↗

Low-density lipoprotein receptor--its structure, function, and mutations.Semantic proximity Read ↗

Inhibition of ApoE4 Endocytosis with LDLR-LA PeptidesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.