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Article

Chromosomal instability (CIN) phenotype, CIN high or CIN low, predicts survival for colorectal cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jun 2012

Watanabe Toshiaki, Kobunai Takashi, Yamamoto Yoko, Matsuda Keiji, Ishihara Soichiro, Nozawa Keijiro, Yamada Hideki, Hayama Tamuro, Inoue Eisuke, Tamura Junko, Iinuma Hisae, Akiyoshi Takashi, Muto Tetsuichiro

Abstract excerpt

PURPOSE: To examine whether chromosomal instability (CIN) phenotype, determined by the severity of CIN, can predict survival for stages II and III colorectal cancer (CRC). PATIENTS AND METHODS: We determined microsatellite instability (MSI) and loss of heterozygosity (LOH) status in 1,103 patients (training [n = 845] and validation [n = 258] sets with stages II and III CRC). The LOH ratio was defined as the...

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PMID: 22547595
DOI: 10.1200/JCO.2011.38.6490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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