Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.

doi:10.1016/j.cell.2005.08.031

Article

Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.

Cell - 4 Nov 2005

Schuldiner Maya, Collins Sean R, Thompson Natalie J, Denic Vladimir, Bhamidipati Arunashree, Punna Thanuja, Ihmels Jan, Andrews Brenda, Boone Charles, Greenblatt Jack F, Weissman Jonathan S, Krogan Nevan J

Abstract excerpt

We present a strategy for generating and analyzing comprehensive genetic-interaction maps, termed E-MAPs (epistatic miniarray profiles), comprising quantitative measures of aggravating or alleviating interactions between gene pairs. Crucial to the interpretation of E-MAPs is their high-density nature made possible by focusing on logically connected gene subsets and including essential genes. Described here is the...

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Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.

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