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Article

Genetic architecture of growth traits revealed by global epistatic interactions.

Genome biology and evolution - 1 Jan 2011

Xu Lin, Jiang Huifeng, Chen Hong, Gu Zhenglong

Abstract excerpt

Epistasis has long been recognized as fundamentally important in understanding the structure, function, and evolutionary dynamics of biological systems. Yet, little is known about how it is distributed underlying specific traits. Based on a global map of epistatic interactions in baker's yeast, Saccharomyces cerevisiae, we show that epistasis is prevalent (∼13% increase from random expectation) and displays...

Topics

Epistasis, Genetic
Evolution, Molecular
Genome, Fungal
Growth
Models, Genetic
Phenotype
Saccharomyces cerevisiae
Sequence Deletion
Systems Biology

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21859803
DOI: 10.1093/gbe/evr065
PMCID: PMC3177326

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