Article
High-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombe.
Nature methods - 1 Oct 2007
Roguev Assen, Wiren Marianna, Weissman Jonathan S, Krogan Nevan J
Abstract excerpt
Epistasis analysis, which reports on the extent to which the function of one gene depends on the presence of a second, is a powerful tool for studying the functional organization of the cell. Systematic genome-wide studies of epistasis, however, have been limited, with the majority of data being collected in the budding yeast, Saccharomyces cerevisiae. Here we present two 'pombe epistasis mapper' strategies,...
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