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Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies.

EBioMedicine - 1 Oct 2023

Leclair Valérie, Galindo-Feria Angeles S, Rothwell Simon, Kryštůfková Olga, Zargar Sepehr Sarrafzadeh, Mann Herman, Diederichsen Louise Pyndt, Andersson Helena, Klein Martin, Tansley Sarah, Rönnblom Lars, Lindblad-Toh Kerstin, Syvänen Ann-Christine, Wahren-Herlenius Marie, Sandling Johanna K, McHugh Neil, Lamb Janine A, Vencovský Jiri, Chinoy Hector, Holmqvist Marie, Bianchi Matteo, Padyukov Leonid, Lundberg Ingrid E, Diaz-Gallo Lina-Marcela

Abstract excerpt

BACKGROUND: In patients with idiopathic inflammatory myopathies (IIM), autoantibodies are associated with specific clinical phenotypes suggesting a pathogenic role of adaptive immunity. We explored if autoantibody profiles are associated with specific HLA genetic variants and clinical manifestations in IIM. METHODS: We included 1348 IIM patients and determined the occurrence of 14 myositis-specific or -associated...

Topics

Humans
Alleles
Autoantibodies
Genetic Predisposition to Disease
Haplotypes
HLA-DRB1 Chains
Myositis
Phenotype

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Identifiers

PMID: 37769433
DOI: 10.1016/j.ebiom.2023.104804
PMCID: PMC10550566

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