Article
Genetic risk and protective factors for idiopathic inflammatory myopathy in Koreans and American whites: a tale of two loci.
Arthritis and rheumatism - 1 Jun 1999
Rider L G, Shamim E, Okada S, Pandey J P, Targoff I N, O'Hanlon T P, Kim H A, Lim Y S, Han H, Song Y W, Miller F W
Abstract excerpt
OBJECTIVE: To better understand genetic contributions to autoimmunity, immunogenetic markers were studied in two racially discrete and geographically isolated populations of patients with idiopathic inflammatory myopathy (IIM). METHODS: Clinical characteristics, as well as clinical and autoantibody subsets, were defined in 151 American white patients and 50 Korean patients with IIM. HLA-DRB1 and DQA1 genotyping...
Topics
- Adult
- Dermatomyositis
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- Histocompatibility Testing
- Humans
- Immunoglobulin Gm Allotypes
- Korea
- Polymerase Chain Reaction
- Risk Factors