Article
HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies.
Arthritis and rheumatism - 1 Nov 2006
O'Hanlon Terrance P, Rider Lisa G, Mamyrova Gulnara, Targoff Ira N, Arnett Frank C, Reveille John D, Carrington Mary, Gao Xiaojiang, Oddis Chester V, Morel Penelope A, Malley James D, Malley Karen, Shamim Ejaz A, Chanock Stephen J, Foster Charles B, Bunch Thomas, Reed Ann M, Love Lori A, Miller Frederick W
Abstract excerpt
OBJECTIVE: To investigate possible associations of HLA polymorphisms with idiopathic inflammatory myopathy (IIM) in African Americans, and to compare this with HLA associations in European American IIM patients with IIM. METHODS: Molecular genetic analyses of HLA-A, B, Cw, DRB1, and DQA1 polymorphisms were performed in a large population of African American patients with IIM (n = 262) in whom the major clinical...
Topics
- Adenosine Triphosphatases
- Adolescent
- Adult
- Black or African American
- Autoantibodies
- Autoantigens
- Child
- DNA Helicases
- Genetic Predisposition to Disease