Article
A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.
Molecular cell - 19 Jan 2017
Yao Zhong, Darowski Katelyn, St-Denis Nicole, Wong Victoria, Offensperger Fabian, Villedieu Annabel, Amin Shahreen, Malty Ramy, Aoki Hiroyuki, Guo Hongbo, Xu Yang, Iorio Caterina, Kotlyar Max, Emili Andrew, Jurisica Igor, Neel Benjamin G, Babu Mohan, Gingras Anne-Claude, Stagljar Igor
Abstract excerpt
Receptor tyrosine kinases (RTKs) and protein phosphatases comprise protein families that play crucial roles in cell signaling. We used two protein-protein interaction (PPI) approaches, the membrane yeast two-hybrid (MYTH) and the mammalian membrane two-hybrid (MaMTH), to map the PPIs between human RTKs and phosphatases. The resulting RTK-phosphatase interactome reveals a considerable number of previously...
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