Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacology and signaling properties of epidermal growth factor receptor isoforms studied by bioluminescence resonance energy transfer.

Molecular pharmacology - 1 Feb 2007

Schiffer Hans H, Reding Esther C, Fuhs Stephen R, Lu Qing, Piu Fabrice, Wong Steven, Littler Pey-Lih H, Weiner Dave M, Keefe William, Tan Phil K, Nash Norman R, Knapp Anne E, Olsson Roger, Brann Mark R

Abstract excerpt

We have developed a new assay for measuring epidermal growth factor receptor (EGFR) activation using the bioluminescence resonance energy transfer (BRET) technology, which directly measures the recruitment of signaling proteins to activated EGFR. Our results demonstrate that EGFR BRET assays prec...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance
Share to ErbB Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescence Resonance Energy Transfer

Share to Luminescent Measurements

Share to Luminescent Proteins

Share to Phosphatidylinositol 3-Kinases

Share to Protein Isoforms

Share to Proto-Oncogene Proteins c-akt

Source

Identifiers

PMID: 16968809
DOI: 10.1124/mol.106.027656

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16968809-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacology and signaling properties of epidermal growth factor receptor isoforms studied by bioluminescence resonance energy transfer.PMID 16968809Read ↗

EGFR signaling and pharmacology in oncology revealed with innovative BRET-based biosensorsSemantic proximity Read ↗

Ligand-Independent EGFR Signaling.Semantic proximity Read ↗

Epidermal growth factor receptor: Role in human cancerSemantic proximity Read ↗

Cell and molecular biology of epidermal growth factor receptor.Semantic proximity Read ↗

Mechanistic insights into the activation of oncogenic forms of EGF receptor.Semantic proximity Read ↗

The epidermal growth factor receptor pathway: a model for targeted therapy.Semantic proximity Read ↗

Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials.Semantic proximity Read ↗

Transactivation of Epidermal Growth Factor Receptor by G Protein-Coupled Receptors: Recent Progress, Challenges and Future ResearchSemantic proximity Read ↗

Mechanisms for oncogenic activation of the epidermal growth factor receptor.Semantic proximity Read ↗

Rapidly Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in NSCLC Cell Lines through De-Repression of FGFR2 and FGFR3 ExpressionSemantic proximity Read ↗

Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib.Semantic proximity Read ↗

Oncogenic mutant forms of EGFR: lessons in signal transduction and targets for cancer therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.