Article
The K-Ras effector p38γ MAPK confers intrinsic resistance to tyrosine kinase inhibitors by stimulating EGFR transcription and EGFR dephosphorylation.
The Journal of biological chemistry - 8 Sept 2017
Yin Ning, Lepp Adrienne, Ji Yongsheng, Mortensen Matthew, Hou Songwang, Qi Xiao-Mei, Myers Charles R, Chen Guan
Abstract excerpt
Mutations in K-Ras and epidermal growth factor receptor (EGFR) are mutually exclusive, but it is not known how K-Ras activation inactivates EGFR, leading to resistance of cancer cells to anti-EGFR therapy. Here, we report that the K-Ras effector p38γ MAPK confers intrinsic resistance to small molecular tyrosine kinase inhibitors (TKIs) by concurrently stimulating EGFR gene transcription and protein...
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