Article
Disrupting the Transmembrane Domain Oligomerization of Protein Tyrosine Phosphatase Receptor J Promotes its Activity in Cancer Cells
2019-06-21
Abstract excerpt
Despite the critical regulatory roles that receptor protein tyrosine phosphatases (RPTP) play in mammalian signal transduction, the detailed structural basis for the regulation of their catalytic activity is not fully understood, nor are they generally therapeutically targetable. It is due, in part, to the lack of known natural ligands or selective agonists. In contrast to conventional structure-function relations...
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Identifiers and source
- Literature Corpus work
- 035f267d-1e93-58b9-a3fd-4c1bbe6051b1
- DOI
- 10.1101/672147