Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PTPα-mediated Src activation by EGF in human breast cancer cells.

Acta biochimica et biophysica Sinica - 1 Apr 2013

Wang Jiamin, Yu Lili, Zheng Xinmin

Abstract excerpt

Protein tyrosine phosphatase alpha (PTPα) functions as an activator of Src by dephosphorylating Tyr527/530, a critical negative regulatory site. The increase of PTPα catalytic activity requires its phosphorylation at Ser180 and/or Ser204 and its dissociation from PTPα/Grb2 complex. Here, we show that epidermal growth factor (EGF) stimulation increases the ability of PTPα to activate Src by dephosphorylating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzopyrans
Share to Biocatalysis
Share to Epidermal Growth Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GRB2 Adaptor Protein

Share to Protein Kinase C-delta

Share to Proto-Oncogene Proteins pp60(c-src)

Share to Serine

Share to Tyrosine

Source

Identifiers

PMID: 23532252
DOI: 10.1093/abbs/gmt005

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PTPα-mediated Src activation by EGF in human breast cancer cells.PMID 23532252Read ↗

Src Continues Aging: Current and Future Clinical DirectionsSemantic proximity Read ↗

Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function.Semantic proximity Read ↗

An alternative role for the src-homology-domain-containing phosphotyrosine phosphatase (SH-PTP2) in regulating epidermal-growth-factor-dependent cell growth.Semantic proximity Read ↗

Src-dependent phosphorylation of the EGF receptor Tyr-845 mediates Stat-p21waf1 pathway in A431 cells.Semantic proximity Read ↗

Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of SrcSemantic proximity Read ↗

Protein tyrosine phosphatase-alpha complexes with the IGF-I receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration.Semantic proximity Read ↗

Cell Transformation by PTP1B Truncated Mutants Found in Human Colon and Thyroid Tumors.Semantic proximity Read ↗

Telomerase Is Controlled by Protein Kinase Cα in Human Breast Cancer CellsSemantic proximity Read ↗

Src SUMOylation Inhibits Tumor Growth Via Decreasing FAK Y925 Phosphorylation.Semantic proximity Read ↗

Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression.Semantic proximity Read ↗

c-Abl regulates estrogen receptor alpha transcription activity through its stabilization by phosphorylation.Semantic proximity Read ↗

Neu-mediated phosphorylation of protein tyrosine phosphatase epsilon is critical for activation of Src in mammary tumor cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.