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Article

HIV-1 Nef Induces Proliferation and Anchorage-Independent Growth in Podocytes

1 Jul 2002

Abstract excerpt

HIV-associated nephropathy (HIVAN) is now the third leading cause of end-stage renal disease in the African American population. HIV-1 infects renal tubular and glomerular epithelial cells or podocytes, cells that are a critical part of the filtration barrier. HIV-1 infection induces the loss of podocyte differentiation markers and increases podocyte proliferation. It has been previously shown that HIV-infection...

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PMID: 12089376
DOI: 10.1097/01.asn.0000019642.55998.69

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