CagA Associates with c‐Met, E‐Cadherin, and p120‐Catenin in a Multiproteic Complex That SuppressesHelicobacter pylori–Induced Cell‐Invasive Phenotype

Abstract excerpt

BACKGROUND: Helicobacter pylori induces an invasive phenotype in gastric epithelial cells through a mechanism that requires the type IV secretion system and the phosphorylation of c-Met. The E-cadherin-catenin complex is a major component of the adherens junctions and functions as an invasion suppressor. We investigated whether E-cadherin has a role in H. pylori-induced, c-Met phosphorylation-dependent...

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