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Article

A novel inhibitory domain of Helicobacter pylori protein CagA reduces CagA effects on host cell biology.

The Journal of biological chemistry - 18 Mar 2011

Pelz Christiane, Steininger Sylvia, Weiss Claudia, Coscia Fabian, Vogelmann Roger

Abstract excerpt

The Helicobacter pylori protein CagA (cytotoxin-associated gene A) is associated with an increased risk for gastric cancer formation. After attachment to epithelial cells, the bacteria inject CagA via a type IV secretion apparatus into host cells, where it exerts its biological activity. Host cell responses to intracellular CagA have been linked exclusively to signaling motifs in the C terminus of the CagA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21212271
DOI: 10.1074/jbc.M110.166504
PMCID: PMC3059056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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