Article
A novel inhibitory domain of Helicobacter pylori protein CagA reduces CagA effects on host cell biology.
The Journal of biological chemistry - 18 Mar 2011
Pelz Christiane, Steininger Sylvia, Weiss Claudia, Coscia Fabian, Vogelmann Roger
Abstract excerpt
The Helicobacter pylori protein CagA (cytotoxin-associated gene A) is associated with an increased risk for gastric cancer formation. After attachment to epithelial cells, the bacteria inject CagA via a type IV secretion apparatus into host cells, where it exerts its biological activity. Host cell responses to intracellular CagA have been linked exclusively to signaling motifs in the C terminus of the CagA...
Topics
- Amino Acid Motifs
- Animals
- Antigens, Bacterial
- Bacterial Proteins
- Cell Line
- Cell Nucleus
- Dogs
- Epithelial Cells
- Helicobacter pylori
- Host-Pathogen Interactions
- Mutation
- Protein Structure, Tertiary
- Risk Factors
- Signal Transduction
- Stomach Neoplasms
- Transcription, Genetic
- beta Catenin