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Article

The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7.

Journal of virology - 1 Nov 2005

Wise-Draper Trisha M, Allen Hillary V, Thobe Megan N, Jones Elizabeth E, Habash Kristen B, Münger Karl, Wells Susanne I

Abstract excerpt

The human DEK proto-oncogene is a nucleic acid binding protein with suspected roles in human carcinogenesis, autoimmune disease, and viral infection. Intracellular DEK functions, however, are poorly understood. In papillomavirus-positive cervical cancer cells, downregulation of viral E6/E7 oncogene expression results in cellular senescence. We report here the specific repression of DEK message and protein levels...

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Topics

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Share to Cellular Senescence
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to Oncogene Proteins

Share to Papillomaviridae

Share to Poly-ADP-Ribose Binding Proteins

Share to Proto-Oncogene Mas

Share to Tumor Virus Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 16254365
DOI: 10.1128/JVI.79.22.14309-14317.2005
PMCID: PMC1280217

Genes

DEK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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