Article
Immortalization of oral keratinocytes by functional inactivation of the p53 and pRb pathways.
International journal of cancer - 1 Apr 2011
Smeets Serge J, van der Plas Marlon, Schaaij-Visser Tieneke B M, van Veen Eva A M, van Meerloo Johan, Braakhuis Boudewijn J M, Steenbergen Renske D M, Brakenhoff Ruud H
Abstract excerpt
A subgroup of head and neck squamous cell carcinomas (HNSCCs) contains high-risk human papillomavirus-type 16 (HPV16). The viral E6 and E7 oncoproteins inactivate the p53 and pRb proteins, respectively. We examined the causative effect of HPV16 E6 and E7 expression on the immortalization of normal oral keratinocytes (OKCs) and compared the resulting phenotype with alternative ways of p53- and pRb-pathway...
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