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Article

Nek6 overexpression antagonizes p53-induced senescence in human cancer cells

1 Dec 2010

Abstract excerpt

Nek6 is an NIMA-related kinase that plays a critical role in mitotic cell cycle progression. Recent studies have shown that Nek6 is upregulated in various human cancers, but the function of Nek6 in tumorigenesis is largely unknown. Here, we examined the role of Nek6 in cellular senescence. Our data revealed that Nek6 expression is decreased both in both the replicative senescence of human normal fibroblasts and...

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PMID: 21099361
DOI: 10.4161/cc.9.23.14059

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