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Article

The human DEK oncogene regulates DNA damage response signaling and repair

7 Jun 2011

Abstract excerpt

The human DEK gene is frequently overexpressed and sometimes amplified in human cancer. Consistent with oncogenic functions, Dek knockout mice are partially resistant to chemically induced papilloma formation. Additionally, DEK knockdown in vitro sensitizes cancer cells to DNA damaging agents and induces cell death via p53-dependent and -independent mechanisms. Here we report that DEK is important for DNA...

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PMID: 21653549
DOI: 10.1093/nar/gkr454

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