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Article

Rapid induction of senescence in human cervical carcinoma cells

26 Sept 2000

Abstract excerpt

Expression of the bovine papillomavirus E2 regulatory protein in human cervical carcinoma cell lines repressed expression of the resident human papillomavirus E6 and E7 oncogenes and within a few days caused essentially all of the cells to synchronously display numerous phenotypic markers characteristic of cells undergoing replicative senescence. This process was accompanied by marked but in some cases transient...

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PMID: 11005870
DOI: 10.1073/pnas.97.20.10978

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