Selection of genetic markers for association analyses, using linkage disequilibrium and haplotypes.

doi:10.1086/376561

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Article

Selection of genetic markers for association analyses, using linkage disequilibrium and haplotypes.

American journal of human genetics - 1 Jul 2003

Meng Zhaoling, Zaykin Dmitri V, Xu Chun-Fang, Wagner Michael, Ehm Margaret G

Abstract excerpt

The genotyping of closely spaced single-nucleotide polymorphism (SNP) markers frequently yields highly correlated data, owing to extensive linkage disequilibrium (LD) between markers. The extent of LD varies widely across the genome and drives the number of frequent haplotypes observed in small r...

Topics

Alleles
Genetic Markers
Haplotypes
Humans
Linkage Disequilibrium
Polymorphism, Single Nucleotide

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