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Article

A developmental requirement for HIRA-dependent H3.3 deposition revealed at gastrulation in Xenopus.

Cell reports - 28 Jun 2012

Szenker Emmanuelle, Lacoste Nicolas, Almouzni Geneviève

Abstract excerpt

Discovering how histone variants that mark distinct chromatin regions affect a developmental program is a major challenge in the epigenetics field. To assess the importance of the H3.3 histone variant and its dedicated histone chaperone HIRA, we used an established developmental model, Xenopus laevis. After the early rapid divisions exploiting a large maternal pool of both replicative H3.2 and replacement H3.3,...

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Source

Identifiers

PMID: 22813747
DOI: 10.1016/j.celrep.2012.05.006

Genes

HIRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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