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Article

Evidence of multiple causal sites affecting weight in the IGF2-INS-TH region of human chromosome 11.

Human genetics - 1 Feb 2002

Gu Dongfeng, O'Dell Sandra D, Chen Xiao-he, Miller George J, Day Ian N M

Abstract excerpt

The subtelomeric region of 11p harbours three closely linked genes, TH, INS and IGF2, that have been associated with obesity, size at birth, type I diabetes, polycystic ovary syndrome, overgrowth in Beckwith-Wiedemann syndrome and possibly hypertension. We have previously shown that the IGF2 ApaI single nucleotide polymorphism (SNP) associates with weight and body mass index in middle-aged Caucasian males but...

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Share to Analysis of Variance
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11935324
DOI: 10.1007/s00439-001-0663-5

Genes

INS
IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Evidence of multiple causal sites affecting weight in the IGF2-INS-TH region of human chromosome 11.PMID 11935324Read ↗

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Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits.Semantic proximity Read ↗

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Family-based association study of IGF1 microsatellites and height, weight, and body mass index.Semantic proximity Read ↗

Associations of IGF2 ApaI RFLP and INS VNTR class I allele size with obesity.Semantic proximity Read ↗

Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans.Semantic proximity Read ↗

Assessment of age-related changes in heritability and IGF-1 gene effect on circulating IGF-1 levels.Semantic proximity Read ↗

Parent-of-origin specific linkage and association of the IGF2 gene region with birth weight and adult metabolic risk factors.Semantic proximity Read ↗

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